News
New 'portal’ identified for drug delivery. http://ecancer.org/news/6144-new----portal----identified-for-drug-delivery.php
Bio-engineered pump could carry cancer drug. http://www.sandiegouniontribune.com/business/biotech/sdut-pumping-cancer-drugs-schnitzer-2014aug30-story.html
How a microscopic 'pump' could get drugs into cancer cells. http://medicalxpress.com/news/2014-08-microscopic-drugs-cancer-cells.html?src_id=alt
Unlikely pairing -- an antidepressant plus dye -- yields tumor-targeting tool. http://www.eurekalert.org/pub_releases/2015-02/uosc-up-021115.php
Molecule blocks cancer growth in mice: New drug candidate disrupts key interaction of two proteins by mimicking one to trick the other. Science Daily, May 13, 2014. http://www.sciencedaily.com/releases/2014/05/140513113655.htm
Selected Publications
Plumbagin-Loaded nanoemulsion drug delivery formulation and evaluation of antiproliferative effect on prostate cancer cells. Chrastina A, Baron VT, Abedinpour P, Rondeau G, Welsh J, Borgstrom P. Biomed Res Int. 2018 Nov 11;2018:9035452. PMID: 30534567.
Known Knowns, Known Unknowns, and Unknown Uknowns: Coverage in MS Experiments. Koziol JA, Li Y, Schnitzer JE. Proteomics. 2018 Aug; 18(16). PMID: 30033555
Differential gene expression induced by anti-cancer agent plumbagin is mediated by androgen receptor in prostate cancer cells. Sci Rep. 2018 Feb 9;8(1): 2694. PMID: 29426892
Plumbagin improves the efficacy of androgen deprivation therapy in prostate cancer: A pre-clinical study. Abedinpour P, Baron VT, Chrastina A, Rondeau G, Pelayo J, Welsh J, Borgstrom P. Prostate. 2017 Dec; 77(16): 1550-1562. PMID: 28971491.
Overcoming key biological barriers to cancer drug delivery and efficacy. Kim SM, Faix PH, Schnitzer JE. J Control Release. 2017 Dec 10; 267: 15-30. PMID: 28917530.
Tumor targeting, trifunctional dendritic wedge. Dubey R, Kushal S, Mollard A, Vojtovich L, Oh P, Levin MD, Schnitzer JE, Zharov I, Olenyuk BZ. Bioconjug Chem. 2015 Jan 21;26(1):78-89. PMID: 25350602
In vivo proteomic imaging analysis of caveolae reveals pumping system to penetrate solid tumors. Oh P, Testa JE, Borgstrom P, Witkiewicz H, Li Y, Schnitzer JE. Nat Med. 2014 Sep;20(9):1062-8. PMID: 25129480
Small Molecule-Directed Efficient Generation of Retinal Pigment Epithelium From Human Pluripotent Stem Cells. Maruotti, J.; Rao Sripathi, S.; Bharti, K.; Fuller, J.; Wahlin, K. J.; Sluch, V.; Ranganathan, V.; Berlinicke, C. A.; Davis, J.; Kim, C.; Zhao, L.; Wan, J.; Qian, J.; Corneo, B.; Temple, S.; Dubey, R.; Olenyuk,* B. Z.; Bhutto,* I. Lutty,* G.; Zack,* D. J., Proc. Natl. Acad. Sci. U. S. A., 2015, 112 (35) 10950-10955. DOI:10.1073/pnas.142281811
Monoamine Oxidase A Inhibitor – Near-Infrared Dye Conjugate Reduces Prostate Tumor Growth. Wu, J. B.; Lin, T.-P.; Gallagher, J. D.; Kushal, S.; Zhau, H. E.; Chung, L. W. K.; Olenyuk,* B. Z.; Shih,* J. C., J. Am. Chem. Soc. 2015, 137, 2366–2374. JACS Cover on February 18, 2015.
Assessing the barriers to image-guided drug delivery. Lanza GM, Moonen C, Baker JR Jr, Chang E, Cheng Z, Grodzinski P, Ferrara K, Hynynen K, Kelloff G, Lee YE, Patri AK, Sept D, Schnitzer JE, Wood BJ, Zhang M, Zheng G, Farahani K. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2014 Jan-Feb;6(1):1-14. PMID: 24339356
In Vivo Anti-Cancer Activity of Rhomboidal Pt(II) Metallacycles. Grishagin, I.V.; Pollock, J. B.; Kushal, S.; Cook, T. R.; Stang,* P. J.; Olenyuk,* B. Z., Proc. Natl. Acad. Sci. U. S. A. 2014, 111, 18448-18453.
Experimental model of transthoracic, vascular-targeted, photodynamically induced myocardial infarction. Chrastina A, Pokreisz P, Schnitzer JE. Am J Physiol Heart Circ Physiol. 2014 Jan 15;306(2):H270-8. PMID: 24213611
On protein abundance distributions in complex mixtures. Koziol J, Griffin N, Long F, Li Y, Latterich M, Schnitzer J. Proteome Sci. 2013 Jan 29;11(1):5. PMID: 23360617
Streamlining biomarker discovery. Latterich M, Schnitzer JE. Nat Biotechnol. 2011 Jul 11;29(7):600-2. PMID: 21747385
Overcoming in vivo barriers to targeted nanodelivery. Chrastina A, Massey KA, Schnitzer JE. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2011 Jul-Aug;3(4):421-37. PMID: 21538941
Systems analysis of endothelial cell plasma membrane proteome of rat lung microvasculature. Li Y, Massey K, Witkiewicz H, Schnitzer JE. Proteome Sci. 2011 Mar 29;9(1):15. PMID: 21447187
Caveolae and Cancer. Massey KA, Schnitzer JE. Recent Results Cancer Res. 2010;180:217-31. PMID: 20033386
Targeting and imaging signature caveolar molecules in lungs. Massey KA, Schnitzer JE. Proc Am Thorac Soc. 2009 Aug 15;6(5):419-30. PMID: 19687214
Live dynamic imaging of caveolae pumping targeted antibody rapidly and specifically across endothelium in the lung. Oh P, Borgström P, Witkiewicz H, Li Y, Borgström BJ, Chrastina A, Iwata K, Zinn KR, Baldwin R, Testa JE, Schnitzer JE. Nat Biotechnol. 2007 Mar;25(3):327-37. Epub 2007 Mar 4. Erratum in: Nat Biotechnol. 2007 Apr;25(4):478. PMID: 17334358
Direct proteomic mapping of the lung microvascular endothelial cell surface in vivo and in cell culture. Durr E, Yu J, Krasinska KM, Carver LA, Yates JR, Testa JE, Oh P, Schnitzer JE. Nat Biotechnol. 2004 Aug;22(8):985-92. PMID: 15258593
Subtractive proteomic mapping of the endothelial surface in lung and solid tumours for tissue-specific therapy. Oh P, Li Y, Yu J, Durr E, Krasinska KM, Carver LA, Testa JE, Schnitzer JE. Nature. 2004 Jun 10;429(6992):629-35. PMID: 15190345